Metabolic Lab

Take the lead on promoting health through diet and exercise.

The overall goal of this lab is to reduce the risk for cardiovascular disease, type 2 diabetes, hypertension, and obesity through diet and exercise interventions.

Students in the Metabolic Lab conduct research on the effect of diet composition and/or exercise on lipids, lipoprotein particle numbers, glycemic control, endothelial dysfunction, blood pressure, and body weight.  Other research conducted in this lab include the effect of eating behaviors on energy intake and hormones that control appetite, and the effect of the eating environment on food choices.

A number of studies conducted in this lab have been in minority populations including Hispanics, African-Americans, and South Asians.

Please contact Dr. Meena Shah if you are interested in working in this area.

Laboratory Projects (selected projects)

  • The effect of a prior bout of aerobic exercise versus no exercise on high-sugar meal induced endothelial dysfunction and glycemic responses in postmenopausal women. Endothelial dysfunction was assessed by measuring postprandial flow mediated dilation and nitric oxide and endothelin-1 concentrations.
  • The effect of an acute bout of aerobic exercise versus no exercise on postprandial blood lipids and lipoprotein particle numbers following a high-sugar meal in postmenopausal women.
  • Comparison of nutrient intakes in South Asians with and without type-2 diabetes. The dietary data were collected at UT Southwestern Medical Center and analyzed by TCU students.
  • The effect of a high-protein versus a high-monounsaturated fat meal on postprandial glycemic responses and appetite ratings in obese subjects. Glycemic control was assessed by measuring postprandial glucagon like peptide-1, insulin, glucagon, C-peptide, and glucose responses, and insulin sensitivity.
  • The effect of a high-protein versus a high-monounsaturated fat meal on postprandial blood lipids, lipoprotein particle numbers, leptin, and cytokine responses in obese subjects.
  • The effect of meal composition on postprandial blood lipid and lipoprotein particle numbers in lean subjects.
  • The effect of menu labels, specifically rank-ordered calorie labels, rank-ordered exercise labels, and no labels, on calories and macronutrients ordered and calories from various foods in Hispanic participants.
  • The effect of exercise labels, calorie labels, and no labels on menus on calories and macronutrients ordered and consumed in young adults.
  • The effect of fast versus slow eating speed on hormones that induce hunger (ghrelin) and satiety (glucagon like peptide-1 and peptide YY) and appetite ratings.
  • The effect of slow versus fast eating rate on ad-libitum energy intake and appetite ratings in lean and obese subjects.
  • The effect of plate size on ad-libitum energy intake in lean and obese subjects.
  • Serving size knowledge in African-American women.
  • Predictors of food label use among college students.
  • The relationship between sleep duration, dietary intake, and body mass index among college students.
  • The relationship between exercise and sleep and health related quality of life in breast cancer patients

 

Publications (selected publications)

Shah M, Adams-Huet B, Franklin B, Phillips M, Mitchell J. The effect of a high-protein versus a high-monounsaturated fat meal on postprandial lipids, lipoprotein particle numbers, cytokines, and leptin responses in overweight/obese subjects. Metabolic Syndrome Related Disorders 2018 Apr;16(3):150-158. doi: 10.1089/met.2017.0167. Epub 2018 Mar 12.

Shah M, Vasandani,C, Adams-Huet B, Garg A. Comparison of Nutrient Intakes in South Asians with Type 2 Diabetes Mellitus and Controls Living in The United States. Diab Res & Clin Prac (2018),138:47-56. DOI: https://doi.org/10.1016/j.diabres.2018.01.016

Shah M, Jaffery M, Adams-Huet B, Franklin B, Oliver J, Mitchell J. (2017) Effect of Meal Composition on Postprandial Lipid Concentrations and Lipoprotein Particle Numbers: A Randomized Cross-Over Study. PLOS ONE DOI:10.1371/journal.pone.0172732. Feb 21, 2017:1-18.

Shah M, Franklin B, Adams-Huet, B, Mitchell J, Bouza B, Dart L, Phillips M.  Effect of Meal Composition on Postprandial Glucagon-Like Peptide-1, Insulin, Glucagon, C-Peptide, and Glucose Responses in Overweight/Obese Subjects. Europ J Nutr 2017;56:1053-1062.  DOI10.1007/s00394-016-1154-8.

Shah M, Bouza B, Adams-Huet B, Jaffery M, Esposito P, Dart L. The Effect of Calorie or Exercise Labels on Menus On Calories and Macronutrients Ordered and Calories from Specific Foods in Hispanic Participants: A Randomized Study. J Investigative Med 2016;64:1261-1268 (epub ahead of print on 7/12/16: DOI 10.1136/jim-2016-000227).

Oliver JM, Almada AL, Van Eck LE, Shah M, Mitchel JB, Jones MT, Jagim AR, Rowlands DS Ingestion of High Molecular Weight Carbohydrate Enhances Subsequent Repeated Maximal Power: A Randomized Controlled Trial. PLOS ONE DOI:10.1371/journal.pone.0163009 September 16, 2016; 1-17.

James A, Adams-Huet B, Shah M. Menu Labels Displaying the Kilocalorie Content or the Exercise Equivalent: Effects on Energy Ordered and Consumed in Young Adults. Am J Hlth Prom; 2015;29(5):294-302 (epub ahead of print on Feb 27, 2014).

Shah M, Crisp K, Adams-Huet B, Dart L, Bouza B, Franklin B, Phillips M. The Effect of Eating Speed at Breakfast on Appetite Hormone Responses and Daily Food Consumption.  J Investigative Med. 2015;63:22-28.

Shah M, Copeland J, Dart L, Adams-Huet B, James A, Rhea D. Slower Eating Speed Lowers Energy Intake in Normal-Weight But Not in Overweight/Obese Subjects. J Acad Nutr Diet 2014;114:393-402.

Shah M, Schroeder R, Winn W, Adams-Huet B. A Pilot Study to Investigate the Effect of Plate Size on Meal Energy Intake in Normal Weight and Overweight/Obese Women. J Hum Nutr Diet 2011;24:612-615.

Shah M, Adams-Huet B, Elston E, Hubbard S, Carson K. Food Serving Size Knowledge in African-American Women and the Relationship with Body Mass Index. J Nutr Educ Behav 2010;42:99-105.